Unilateral or bilateral craniocervical pain with variable presentation, with or without sensory changes, attributed to a demyelinating lesion of the central ascending connections of the trigeminal nerve in a person with multiple sclerosis. It commonly remits and relapses.
- Facial and/or head pain fulfilling criterion C1
- Multiple sclerosis has been diagnosed, with MRI demonstration of a demyelinating lesion in the brain stem or ascending projections of the trigeminal nuclei
- Pain has developed in temporal relation to to the demyelinating lesion, or led to its discovery
- Not better accounted for by another ICHD-3 diagnosis.
Pain may be paroxysmal or continuous.
Non-painful sensory abnormalities (usually dysaesthesia but also hypaesthesia, anaesthesia, hypalgesia, paraesthesia, etc) may coexist with pain in 13.13.1 Central neuropathic pain attributed to multiple sclerosis.