7.3.4 Headache attributed to lymphocytic hypophysitisHartmut Gobel2018-01-31T10:28:54+00:00
Description:
Headache caused by lymphocytic hypophysitis, associated with pituitary enlargement and, in half of cases, with hyperprolactinaemia. It remits after successful treatment of the lymphocytic hypophysitis.
Diagnostic criteria:
- Any headache fulfilling criterion C
- Lymphocytic hypophysitis has been diagnosed
- Evidence of causation demonstrated by one or more of the following:
- headache has developed in temporal relation to the onset of the lymphocytic hypophysitis
- headache has significantly worsened in parallel with worsening of the lymphocytic hypophysitis
- headache has significantly improved in parallel with improvement in the lymphocytic hypophysitis
- Not better accounted for by another ICHD-3 diagnosis.
Comments:
Lymphocytic hypophysitis is associated with pituitary enlargement and homogeneous contrast enhancement on brain MRI. It is accompanied by hyperprolactinaemia in 50% of cases or autoantibodies against hypophyseal cytosol protein in 20% of cases.
The disorder typically develops at the end of pregnancy or during the post-partum period, but it can also occur in men.